Endocrine Abstracts

A 29-year-old lady with known autoimmune thyrotoxicosis (TPO 712 IU/ml) presented with an urticarial rash. She was on carbimazole. A diagnosis of drug-induced reaction was suspected and treated as such. Her carbimazole was discontinued. After a day of treatment with steroids and antihistamines, she experienced flushing, orthostatic hypotension and difficulty in breathing. She was treated for anaphylaxis with adrenaline on intensive care unit. A formal Dermatology opinion was p...

A 38-year old lady from the Philippines presented with a 2-year history of a painless thyroid lump, without pressure symptoms. Over the previous year it had gradually enlarged in size. She gave a history of disturbed sleep, tremor, anxiety and weight loss over the 2-year period. Past medical history included right middle lobectomy for bronchiectasis 10 years previously. Thyroid function tests revealed TSH<0.05 mu/l, FT4 86 pmol/l, FT3 18.3 pmol/l and ...

Adrenocortical carcinoma is extremely rare and accounts for 0.05–2% of all malignant neoplasms with an estimated incidence of 0.5–2% per million people per year. Feminising adrenal carcinoma is even rarer. We submit such a rare case presenting with gynaecomastia.A 50 year old man presented with a year history of increasing bilateral gynaecomastia. He had no problems with his sexual function. Initial investigations by the GP showed low testoster...

We report two patients (AB 41 years, LS 55 years) presenting with symptoms of hyperprolactinaemia. Prolactin levels were moderately elevated: 1539 (AB), 1186 (LS) (NR 59-619 mU/L). The remainder of the pituitary profile was normal. Neither patient had visual field defects. MRIs (without contrast) reported pituitary macroadenoma with suprasellar extension but no optic chiasm compression. The initial diagnosis was of probable non-functioning adenoma causing stalk compression. Bo...